IndiumV2, Main, Exploration, bibRecord, 000C66

Indium-promoted Reformatsky reaction: a straightforward access to β-amino and β-hydroxy α,α-difluoro carbonyl compounds.

Identifieur interne : 000C66 ( Main/Exploration ); précédent : 000C65; suivant : 000C67

Indium-promoted Reformatsky reaction: a straightforward access to β-amino and β-hydroxy α,α-difluoro carbonyl compounds.

Auteurs : RBID : pubmed:22998653

English descriptors

KwdEn :
- Aldehydes (chemistry), Hydrocarbons, Fluorinated (chemical synthesis), Hydrocarbons, Fluorinated (chemistry), Imines (chemistry), Indium (chemistry), Ketones (chemistry), Molecular Structure.
MESH :
- chemical , chemical synthesis : Hydrocarbons, Fluorinated.
- chemical , chemistry : Aldehydes, Hydrocarbons, Fluorinated, Imines, Indium, Ketones.
- Molecular Structure.

Abstract

A versatile and practical methodology to access β-amino and β-hydroxy α,α-difluoro carbonyl compounds using indium metal is described. This methodology has been successfully applied to a broad range of substrates including aldehydes, ketones, and imines, affording the corresponding and highly valuable gem-difluoro esters. The wide substrate scope highlights the chemoselectivity of the process.

DOI: 10.1021/jo301873y
PubMed: 22998653

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000A38
to stream Main, to step Curation: 000A38

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Indium-promoted Reformatsky reaction: a straightforward access to β-amino and β-hydroxy α,α-difluoro carbonyl compounds.</title>
<author><name sortKey="Poisson, Thomas" uniqKey="Poisson T">Thomas Poisson</name>
<affiliation wicri:level="3"><nlm:affiliation>INSA de Rouen, Avenue de l'Université, 76800 St Etienne du Rouvray, France. thomas.poisson@insa-rouen.fr</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSA de Rouen, Avenue de l'Université, 76800 St Etienne du Rouvray</wicri:regionArea>
<placeName><region type="region" nuts="2">Haute-Normandie</region>
<settlement type="city">St Etienne du Rouvray</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Belhomme, Marie Charlotte" uniqKey="Belhomme M">Marie-Charlotte Belhomme</name>
</author>
<author><name sortKey="Pannecoucke, Xavier" uniqKey="Pannecoucke X">Xavier Pannecoucke</name>
</author>
</titleStmt>
<publicationStmt><date when="2012">2012</date>
<idno type="doi">10.1021/jo301873y</idno>
<idno type="RBID">pubmed:22998653</idno>
<idno type="pmid">22998653</idno>
<idno type="wicri:Area/Main/Corpus">000A38</idno>
<idno type="wicri:Area/Main/Curation">000A38</idno>
<idno type="wicri:Area/Main/Exploration">000C66</idno>
</publicationStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aldehydes (chemistry)</term>
<term>Hydrocarbons, Fluorinated (chemical synthesis)</term>
<term>Hydrocarbons, Fluorinated (chemistry)</term>
<term>Imines (chemistry)</term>
<term>Indium (chemistry)</term>
<term>Ketones (chemistry)</term>
<term>Molecular Structure</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemical synthesis" xml:lang="en"><term>Hydrocarbons, Fluorinated</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Aldehydes</term>
<term>Hydrocarbons, Fluorinated</term>
<term>Imines</term>
<term>Indium</term>
<term>Ketones</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Molecular Structure</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">A versatile and practical methodology to access β-amino and β-hydroxy α,α-difluoro carbonyl compounds using indium metal is described. This methodology has been successfully applied to a broad range of substrates including aldehydes, ketones, and imines, affording the corresponding and highly valuable gem-difluoro esters. The wide substrate scope highlights the chemoselectivity of the process.</div>
</front>
</TEI>
<pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">22998653</PMID>
<DateCreated><Year>2012</Year>
<Month>10</Month>
<Day>19</Day>
</DateCreated>
<DateCompleted><Year>2013</Year>
<Month>03</Month>
<Day>22</Day>
</DateCompleted>
<DateRevised><Year>2013</Year>
<Month>11</Month>
<Day>21</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1520-6904</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>77</Volume>
<Issue>20</Issue>
<PubDate><Year>2012</Year>
<Month>Oct</Month>
<Day>19</Day>
</PubDate>
</JournalIssue>
<Title>The Journal of organic chemistry</Title>
<ISOAbbreviation>J. Org. Chem.</ISOAbbreviation>
</Journal>
<ArticleTitle>Indium-promoted Reformatsky reaction: a straightforward access to β-amino and β-hydroxy α,α-difluoro carbonyl compounds.</ArticleTitle>
<Pagination><MedlinePgn>9277-85</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1021/jo301873y</ELocationID>
<Abstract><AbstractText>A versatile and practical methodology to access β-amino and β-hydroxy α,α-difluoro carbonyl compounds using indium metal is described. This methodology has been successfully applied to a broad range of substrates including aldehydes, ketones, and imines, affording the corresponding and highly valuable gem-difluoro esters. The wide substrate scope highlights the chemoselectivity of the process.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Poisson</LastName>
<ForeName>Thomas</ForeName>
<Initials>T</Initials>
<Affiliation>INSA de Rouen, Avenue de l'Université, 76800 St Etienne du Rouvray, France. thomas.poisson@insa-rouen.fr</Affiliation>
</Author>
<Author ValidYN="Y"><LastName>Belhomme</LastName>
<ForeName>Marie-Charlotte</ForeName>
<Initials>MC</Initials>
</Author>
<Author ValidYN="Y"><LastName>Pannecoucke</LastName>
<ForeName>Xavier</ForeName>
<Initials>X</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType>Journal Article</PublicationType>
<PublicationType>Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2012</Year>
<Month>10</Month>
<Day>08</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>J Org Chem</MedlineTA>
<NlmUniqueID>2985193R</NlmUniqueID>
<ISSNLinking>0022-3263</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance>Aldehydes</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance>Hydrocarbons, Fluorinated</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance>Imines</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance>Ketones</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>045A6V3VFX</RegistryNumber>
<NameOfSubstance>Indium</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Aldehydes</DescriptorName>
<QualifierName MajorTopicYN="N">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N">Hydrocarbons, Fluorinated</DescriptorName>
<QualifierName MajorTopicYN="Y">chemical synthesis</QualifierName>
<QualifierName MajorTopicYN="N">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N">Imines</DescriptorName>
<QualifierName MajorTopicYN="N">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N">Indium</DescriptorName>
<QualifierName MajorTopicYN="Y">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N">Ketones</DescriptorName>
<QualifierName MajorTopicYN="N">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N">Molecular Structure</DescriptorName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="aheadofprint"><Year>2012</Year>
<Month>10</Month>
<Day>8</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2012</Year>
<Month>9</Month>
<Day>25</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2012</Year>
<Month>9</Month>
<Day>25</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2013</Year>
<Month>3</Month>
<Day>23</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="doi">10.1021/jo301873y</ArticleId>
<ArticleId IdType="pubmed">22998653</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=IndiumV2/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000C66 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000C66 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=   *** parameter Area/wikiCode missing *** 
   |area=    IndiumV2
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:22998653
   |texte=   Indium-promoted Reformatsky reaction: a straightforward access to β-amino and β-hydroxy α,α-difluoro carbonyl compounds.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:22998653" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a IndiumV2

This area was generated with Dilib version V0.5.76.
Data generation: Tue May 20 07:24:43 2014. Site generation: Thu Mar 7 11:12:53 2024

	Serveur d'exploration sur l'Indium
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur l'Indium

Indium-promoted Reformatsky reaction: a straightforward access to β-amino and β-hydroxy α,α-difluoro carbonyl compounds.

Indium-promoted Reformatsky reaction: a straightforward access to β-amino and β-hydroxy α,α-difluoro carbonyl compounds.

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki